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It depends on how much larger the large pizza is compared to the medium.
Okay, great answer. But how do you really find out?
Let’s make the assumption that the calorie content of the crust is not important, and that both pizzas have the same thickness and distribution of toppings. If you have a pizza with a four inch radius (8 inch diameter) as your medium, the area of the pizza is going to be 3.14*4^2 (the radius squared times pi). The area of the pizza, which is about 50 square inches, is equal to 260 calories.
The amount of calories divided by the amount of square inches gives you the calories per square inch, which in this example, is 5.2. From here, you should use area formula (the radius squared times pi) on the large pizza to find the area.
Multiply the area in square inches by your constant for calories per square inch to find the number of calories in a large pizza. Voila! Mathematics prevails!